Accio Biobank Online specimens from a 101 year old donor played a central role in a groundbreaking paper out today in the prestigious Cell Reports journal: Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.
Highlights of the reports are:
- •Ovarian cancer can be detected by ultra-accurate sequencing of uterine lavage DNA
- •However, low-frequency TP53 mutations also exist in normal tissue of healthy women
- •TP53 mutations are increasingly selected for with age, revealing somatic evolution
- •Age-associated, cancer-like mutations challenge specificity for cancer detection
We are extremely pleased that specimens from our biobank contributed to this research.
You can read the full report here.
