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Tissue For Research’s Specimens in Cell Reports

Tissue For Research specimens from a 101 year old donor played a central role in a groundbreaking paper out today in the prestigious Cell Reports journal: Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Highlights


  • Ovarian cancer can be detected by ultra-accurate sequencing of uterine lavage DNA

  • However, low-frequency TP53 mutations also exist in normal tissue of healthy women

  • TP53 mutations are increasingly selected for with age, revealing somatic evolution

  • Age-associated, cancer-like mutations challenge specificity for cancer detection
Tissue specimen report

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