Highlights of the reports are:
- Ovarian cancer can be detected by ultra-accurate sequencing of uterine lavage DNA•
However, low-frequency - TP53 mutations also exist in normal tissue of healthy women
- Age-associated, cancer-like mutations challenge specificity for cancer detection
- TP53 mutations are increasingly selected for with age, revealing somatic evolution
We are extremely pleased that specimens from our biobank contributed to this research.You can read the full report here.
Ovarian cancer detection and clonal selection of mutations in normal uterine tissue reveals somatic evolution and challenges specificity of cancer detection